Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

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Musdal Y., Ertan-Bolelli T., Bolelli K., Yilmaz S., Ceyhan D., Hegazy U., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.37, no.4, pp.431-436, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 37 Issue: 4
• Publication Date: 2012
• Doi Number: 10.5505/tjb.2012.30301
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.431-436
• Hacettepe University Affiliated: Yes

Abstract

Objective: Glutathione transferases (GST) are multifunctional enzymes involved in detoxication, drug resistance, cell signaling and apoptosis. The inhibitory effects of novel benzazole derivatives were tested on human GST P1-1 to find new agents for overcoming drug resistance in cancer cells.