Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

Musdal, YAMAN; Ertan-Bolelli, Tugba; Bolelli, Kayhan; Yilmaz, Serap; Ceyhan, DENİZ; Hegazy, Usama; Mannervik, Bengt; Aksoy, YASEMİN

doi:10.5505/tjb.2012.30301

Inhibition of human glutathione transferase P1-1 by novel benzazole derivatives

Musdal Y., Ertan-Bolelli T., Bolelli K., Yilmaz S., Ceyhan D., Hegazy U., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.37, sa.4, ss.431-436, 2012 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 37 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.5505/tjb.2012.30301
Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.431-436
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Glutathione transferases (GST) are multifunctional enzymes involved in detoxication, drug resistance, cell signaling and apoptosis. The inhibitory effects of novel benzazole derivatives were tested on human GST P1-1 to find new agents for overcoming drug resistance in cancer cells.