Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens


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Kavruk M., ÇELİKBIÇAK Ö., Ozalp V. C., Borsa B. A., Hernandez F. J., Bayramoglu G., ...More

CHEMICAL COMMUNICATIONS, vol.51, no.40, pp.8492-8495, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 40
  • Publication Date: 2015
  • Doi Number: 10.1039/c5cc01869b
  • Journal Name: CHEMICAL COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8492-8495
  • Hacettepe University Affiliated: Yes

Abstract

In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer–receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.