Functional impact of CYP2C*5, CYP2C9*6, CYP2C9*8, and CYP2C9*11 in vivo among black Africans

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Allabi A., Gala J., Horsmans Y., Babaoglu M., Bozkurt A., Heusterspreute M., ...More

CLINICAL PHARMACOLOGY & THERAPEUTICS, vol.76, no.2, pp.113-118, 2004 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 76 Issue: 2
• Publication Date: 2004
• Doi Number: 10.1016/j.clpt.2004.04.001
• Journal Name: CLINICAL PHARMACOLOGY & THERAPEUTICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.113-118
• Hacettepe University Affiliated: Yes

Abstract

Background and Aim: Previous data indicate that the urinary losartan/E-3174 ratio is a marker for cytochrome P450 (CYP) 2C9 activity in vivo. The functional impact of CYP2C9(star)5, (star)6, (star)8, and (star)11 polymorphisms in vivo has not been investigated previously in humans.