A rare gamma-pyranopyrazole skeleton: design, one-pot synthesis and computational study

Creative Commons License

Ucuncu M., Canturk C., Karakus E., Zeybek H., BOZKAYA U., Soydas E., ...Daha Fazla

ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.14, sa.31, ss.7490-7494, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 31
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c6ob01099g
  • Dergi Adı: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7490-7494
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straight-forward synthetic route has been developed for a range of pyrazole fused gamma-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of gamma-pyranopyrazole is furthermore fully supported by experimental and computational studies.