A rare gamma-pyranopyrazole skeleton: design, one-pot synthesis and computational study
ORGANIC & BIOMOLECULAR CHEMISTRY, vol.14, no.31, pp.7490-7494, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 14 Issue: 31
- Publication Date: 2016
- Doi Number: 10.1039/c6ob01099g
- Journal Name: ORGANIC & BIOMOLECULAR CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.7490-7494
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straight-forward synthetic route has been developed for a range of pyrazole fused gamma-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of gamma-pyranopyrazole is furthermore fully supported by experimental and computational studies.