A rare gamma-pyranopyrazole skeleton: design, one-pot synthesis and computational study


Ucuncu M., Canturk C., Karakus E., Zeybek H., BOZKAYA U. , Soydas E., ...Daha Fazla

ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.14, ss.7490-7494, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 14 Konu: 31
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c6ob01099g
  • Dergi Adı: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Sayfa Sayıları: ss.7490-7494

Özet

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straight-forward synthetic route has been developed for a range of pyrazole fused gamma-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of gamma-pyranopyrazole is furthermore fully supported by experimental and computational studies.