The UniProtKB guide to the human proteome


Breuza L., Poux S., Estreicher A., Famiglietti M. L. , Magrane M., Tognolli M., ...Daha Fazla

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası:
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1093/database/bav120
  • Dergi Adı: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION

Özet

Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.