The UniProtKB guide to the human proteome

Breuza, Lionel; Poux, Sylvain; Estreicher, Anne; Famiglietti, Maria; Magrane, Michele; Tognolli, Michael; Bridge, Alan; Baratin, Delphine; Redaschi, Nicole; Xenarios, Ioannis; Bougueleret, Lydie; Bairoch, Amos; Aimo, Lucila; Auchincloss, Andrea; Axelsen, Kristian; Argoud-Puy, Ghislaine; Bansal, Parit; Binz, Pierre-Alain; Blatter, Marie-Claude; Boeckmann, Brigitte; Bolleman, Jerven; Boutet, Emmanuel; Braconi-Quintaje, Silvia; Casal-Casas, Cristina; de Castro, Edouard; Cerutti, Lorenzo; Coudert, Elisabeth; Cuche, Beatrice; Cusin, Isabelle; Doche, Mikael; Dornevil, Dolnide; Duvaud, Severine; Ferro-Rojas, Serenella; Feuermann, Marc; Gasteiger, Elisabeth; Gehant, Sebastien; Gerritsen, Vivienne; Gos, Arnaud; Gruaz-Gumowski, Nadine; Hinz, Ursula; Hulo, Chantal; James, Janet; Jimenez, Silvia; Jungo, Florence; Keller, Guillaume; Kerhornou, Arnaud; Kappler, Thomas; Lane, Lydie; Lara, Vicente; Lemercier, Philippe; Lieberherr, Damien; Lombardot, Thierry; Martin, Xavier; Masson, Patrick; Moinat, Madelaine; Morgat, Anne; Neto, Teresa; Paesano, Salvo; Pedruzzi, Ivo; Pilbout, Sandrine; Pozzato, Monica; Pruess, Manuela; Rivoire, Catherine; Roechert, Bernd; Schneider, Michel; Sigrist, Christian; Sonesson, Karin; Staehli, Sylvie; Stutz, Andre; Sundaram, Shyamala; Verbregue, Laure; Veuthey, Anne-Lise; Bateman, Alex; Martin, Maria; O'Donovan, Claire; Apweiler, Rolf; Alpi, Emanuele; Antunes, Ricardo; Argasinska, Joanna; Bely, Benoit; Bingley, Mark; Bonilla, Carlos; Britto, Ramona; Bursteinas, Borisas; Bye-A-Jee, Hema; Courtot, Melanie; Da Silva, Alan; De Giorgi, Maurizio; Dogan, TUNCA; Castro, Leyla; Garmiri, Penelope; Gonzalez, Daniel; Hatton-Ellis, Emma; Liu, Wudong; Luo, Jie; MacDougall, Alistair; Nightingale, Andrew; Onwubiko, Joseph; Palka, Barbara; Pichler, Klemens; Poggioli, Diego; Pundir, Sangya; Pureza, Luis; Qi, Guoying; Renaux, Alexandre; Rosanoff, Steven; Saidi, Rabie; Sawford, Tony; Shypitsyna, Aleksandra; Speretta, Elena; Turner, Edward; Tyagi, Nidhi; Volynkin, Vladimir; Wardell, Tony; Warner, Kate; Watkins, Xavier; Zaru, Rossana; Zellner, Hermann; Cowley, Andrew; Figueira, Luis; Li, Weizhong; McWilliam, Hamish; Lopez, Rodrigo; Wu, Cathy; Arighi, Cecilia; Arminski, Leslie; Chen, Chuming; Chen, Yongxing; Garavelli, John; Huang, Hongzhan; Laiho, Kati; McGarvey, Peter; Natale, Darren; Suzek, Baris; Vinayaka, C.; Wang, Qinghua; Wang, Yuqi; Yeh, Lai-Su; Yerramalla, Meher; Zhang, Jian

doi:10.1093/database/bav120

The UniProtKB guide to the human proteome

Breuza L., Poux S., Estreicher A., Famiglietti M. L., Magrane M., Tognolli M., ...More

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume:
Publication Date: 2016
Doi Number: 10.1093/database/bav120
Journal Name: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: No

Abstract

Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.