The UniProtKB guide to the human proteome

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Breuza L., Poux S., Estreicher A., Famiglietti M. L., Magrane M., Tognolli M., ...More

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2016 (SCI-Expanded) identifier identifier identifier


Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.