Increased Frequency of Extremely Skewed X Chromosome Inactivation in Juvenile Idiopathic Arthritis

Uz E., Mustafa C., TOPALOĞLU R., BİLGİNER Y., DURSUN A., KASAPÇOPUR Ö., ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.60, sa.11, ss.3410-3412, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 11
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/art.24956
  • Dergi Adı: ARTHRITIS AND RHEUMATISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3410-3412
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.