Increased Frequency of Extremely Skewed X Chromosome Inactivation in Juvenile Idiopathic Arthritis
ARTHRITIS AND RHEUMATISM, cilt.60, sa.11, ss.3410-3412, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 60 Sayı: 11
- Basım Tarihi: 2009
- Doi Numarası: 10.1002/art.24956
- Dergi Adı: ARTHRITIS AND RHEUMATISM
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.3410-3412
- Hacettepe Üniversitesi Adresli: Evet
Özet
Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.