Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis

Yilmaz D., ÇAĞLAYAN F., BÜBER E., Kononen E., AKSOY Y., Gursoy U. K., ...More

CLINICAL ORAL INVESTIGATIONS, vol.22, no.5, pp.2135-2140, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1007/s00784-018-2469-z
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2135-2140
  • Keywords: Antimicrobial peptides, Diabetes mellitus, Periodontitis, Gingival crevicular fluid, GENE-EXPRESSION, DEFENSINS, GLUCOSE, HEALTH, HBD-2
  • Hacettepe University Affiliated: Yes


Objectives Human beta-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals.