Glucosides from Vitex agnus-castus

KURUUZUM-UZ A., STROCH K., Demirezer L. Ö., ZEECK A.

PHYTOCHEMISTRY, vol.63, no.8, pp.959-964, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 8
  • Publication Date: 2003
  • Doi Number: 10.1016/s0031-9422(03)00285-1
  • Journal Name: PHYTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.959-964
  • Keywords: Vitex agnus-castus, Verbenaceae, iridoid glucosides, aucubin, mussaenosidic acids, agnucastosides A-C, myzodendrone, IRIDOID GLUCOSIDES, FRUITS, ROTUNDIFOLIA, GLYCOSIDE, NEGUNDO, ACID, FLAVONOIDS
  • Hacettepe University Affiliated: Yes

Abstract

The methanolic extract of the flowering steins of Vitex agnus-castus yielded three new iridoids: 6'-O-foliamenthoylmussaenosidic acid (agnucastoside A), 6'-O-(6,7-dihydrofoliamenthoyl)mussaenosidic acid (agnucastoside B) and 7-O-trans-p-coumaroyl-6'-O-trans-caffeoyl-8-epiloganic acid (agnucastoside C) in addition to four known iridoids (aucubin, agnuside, mussaenosidic acid and 6'O-p-hydroxybenzoylmussaenosidic acid) and one known phenylbutanone glucoside (myzodendrone). The structure elucidations were mainly done by spectroscopic methods (1D and 2D NMR spectra) and MS data interpretation. The purified compounds were tested for biological activities against various microorganisms and cancer cell lilies. (C) 2003 Elsevier Ltd. All rights reserved.