c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastases

Yucel, ÖMER; Sungur, A; Kaya, S

doi:10.1016/j.otohns.2003.09.031

c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastases

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Yucel O., Sungur A., Kaya S.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, vol.130, no.6, pp.698-703, 2004 (SCI-Expanded)

Publication Type: Article / Article
Volume: 130 Issue: 6
Publication Date: 2004
Doi Number: 10.1016/j.otohns.2003.09.031
Journal Name: OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.698-703
Hacettepe University Affiliated: Yes

Abstract

BACKGROUND: The c-met oncogene encodes the receptor for the hepatocyte growth factor/scatter factor (HGF/SF), which is known to have the effects of stimulation of cell motility, dissociation of epithelial sheets, invasion of cellular matrix, and induction of angiogenesis. Many studies in solid tumors have indicated a role for c-met and HGF/SF in the progression of the disease.