c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastases


Yucel O. , Sungur A., Kaya S.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, vol.130, no.6, pp.698-703, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 130 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1016/j.otohns.2003.09.031
  • Title of Journal : OTOLARYNGOLOGY-HEAD AND NECK SURGERY
  • Page Numbers: pp.698-703

Abstract

BACKGROUND: The c-met oncogene encodes the receptor for the hepatocyte growth factor/scatter factor (HGF/SF), which is known to have the effects of stimulation of cell motility, dissociation of epithelial sheets, invasion of cellular matrix, and induction of angiogenesis. Many studies in solid tumors have indicated a role for c-met and HGF/SF in the progression of the disease.