c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastases


Yucel O. , Sungur A., Kaya S.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, cilt.130, ss.698-703, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 130 Konu: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.otohns.2003.09.031
  • Dergi Adı: OTOLARYNGOLOGY-HEAD AND NECK SURGERY
  • Sayfa Sayıları: ss.698-703

Özet

BACKGROUND: The c-met oncogene encodes the receptor for the hepatocyte growth factor/scatter factor (HGF/SF), which is known to have the effects of stimulation of cell motility, dissociation of epithelial sheets, invasion of cellular matrix, and induction of angiogenesis. Many studies in solid tumors have indicated a role for c-met and HGF/SF in the progression of the disease.