c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastases

Yucel O., Sungur A., Kaya S.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, cilt.130, sa.6, ss.698-703, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 130 Sayı: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.otohns.2003.09.031
  • Dergi Adı: OTOLARYNGOLOGY-HEAD AND NECK SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.698-703
  • Hacettepe Üniversitesi Adresli: Evet

Özet

BACKGROUND: The c-met oncogene encodes the receptor for the hepatocyte growth factor/scatter factor (HGF/SF), which is known to have the effects of stimulation of cell motility, dissociation of epithelial sheets, invasion of cellular matrix, and induction of angiogenesis. Many studies in solid tumors have indicated a role for c-met and HGF/SF in the progression of the disease.