The Impact of Vitamin D on Response to Anti-tumor Necrosis Factor-alpha Therapy in Children With Inflammatory Bowel Disease
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, cilt.72, sa.5, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72 Sayı: 5
- Basım Tarihi: 2021
- Doi Numarası: 10.1097/mpg.0000000000003064
- Dergi Adı: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Hacettepe Üniversitesi Adresli: Evet
Özet
Objectives: Experimental studies have shown that vitamin D has an immunomodulatory effect on the innate and adaptive immune systems. Associations between vitamin D deficiency and development or progression of inflammatory bowel diseases (IBDs) are reported, but a cause-and-effect relationship between pretreatment 25 hydroxyvitamin D [25(OH)D] levels and response to anti-tumor necrosis factor-alpha (anti-TNF) therapy is not established.