The Impact of Vitamin D on Response to Anti-tumor Necrosis Factor-alpha Therapy in Children With Inflammatory Bowel Disease


Hizarcioglu-Gulsen H., Kaplan J. L., Moran C. J., Israel E. J., Lee H., Winter H.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol.72, no.5, 2021 (SCI-Expanded) identifier identifier identifier

Abstract

Objectives: Experimental studies have shown that vitamin D has an immunomodulatory effect on the innate and adaptive immune systems. Associations between vitamin D deficiency and development or progression of inflammatory bowel diseases (IBDs) are reported, but a cause-and-effect relationship between pretreatment 25 hydroxyvitamin D [25(OH)D] levels and response to anti-tumor necrosis factor-alpha (anti-TNF) therapy is not established.