The Impact of Vitamin D on Response to Anti-tumor Necrosis Factor-alpha Therapy in Children With Inflammatory Bowel Disease

Hizarcioglu-Gulsen H., Kaplan J. L., Moran C. J., Israel E. J., Lee H., Winter H.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, cilt.72, sa.5, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1097/mpg.0000000000003064
  • Dergi Adı: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives: Experimental studies have shown that vitamin D has an immunomodulatory effect on the innate and adaptive immune systems. Associations between vitamin D deficiency and development or progression of inflammatory bowel diseases (IBDs) are reported, but a cause-and-effect relationship between pretreatment 25 hydroxyvitamin D [25(OH)D] levels and response to anti-tumor necrosis factor-alpha (anti-TNF) therapy is not established.