Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.37, no.6, pp.519-523, 2002 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 37 Issue: 6
- Publication Date: 2002
- Doi Number: 10.1016/s0223-5234(02)01374-0
- Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.519-523
- Hacettepe University Affiliated: Yes
Abstract
In this study, 1;2 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and. their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11 > pinacidil > 7 > 2 > 8 > 3 > 1 > 4 > 10 > 6 > 9 > 5 > 12. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.