Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries


Berkan O. C., Sarac B., Simsek R., Yildirim S., Sarioglu Y., Safak C.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.37, no.6, pp.519-523, 2002 (SCI-Expanded) identifier identifier

Abstract

In this study, 1;2 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and. their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11 > pinacidil > 7 > 2 > 8 > 3 > 1 > 4 > 10 > 6 > 9 > 5 > 12. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.