A Review of Statin Intolerance: a Focus on Statin-Attributed Muscle Symptoms

Orringer C. E., Grant J. K., Tokgozoglu L.

CURRENT ATHEROSCLEROSIS REPORTS, cilt.24, sa.11, ss.839-847, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11883-022-01059-x
  • Dergi Adı: CURRENT ATHEROSCLEROSIS REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.839-847
  • Anahtar Kelimeler: Statin intolerance, Statin-associated muscle symptoms, Nocebo effect, CORONARY-ARTERY CALCIUM, CARDIOVASCULAR-DISEASE, PRIMARY PREVENTION, INDIVIDUAL DATA, POSITION PAPER, THERAPY, MANAGEMENT, METAANALYSIS, CHOLESTEROL, EFFICACY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose of Review To provide a systematic approach to management of the patient with statin-attributed muscle symptoms. Recent Findings We examined the prevalence of statin intolerance, the role of the nocebo effect, key findings in the patient's history and laboratory studies, the potential value of coronary calcium scoring, and the importance of shared decision-making in considering statin re-initiation. Most patients with statin-attributed muscle symptoms can be successfully treated with statins or a combination of statins and non-statins to achieve successful ASCVD risk reduction.