A Review of Statin Intolerance: a Focus on Statin-Attributed Muscle Symptoms

Orringer C. E., Grant J. K., Tokgozoglu L.

CURRENT ATHEROSCLEROSIS REPORTS, vol.24, no.11, pp.839-847, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 24 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.1007/s11883-022-01059-x
  • Journal Name: CURRENT ATHEROSCLEROSIS REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.839-847
  • Keywords: Statin intolerance, Statin-associated muscle symptoms, Nocebo effect, CORONARY-ARTERY CALCIUM, CARDIOVASCULAR-DISEASE, PRIMARY PREVENTION, INDIVIDUAL DATA, POSITION PAPER, THERAPY, MANAGEMENT, METAANALYSIS, CHOLESTEROL, EFFICACY
  • Hacettepe University Affiliated: Yes

Abstract

Purpose of Review To provide a systematic approach to management of the patient with statin-attributed muscle symptoms. Recent Findings We examined the prevalence of statin intolerance, the role of the nocebo effect, key findings in the patient's history and laboratory studies, the potential value of coronary calcium scoring, and the importance of shared decision-making in considering statin re-initiation. Most patients with statin-attributed muscle symptoms can be successfully treated with statins or a combination of statins and non-statins to achieve successful ASCVD risk reduction.