Comparison of Growth Hormone Receptor, IGF-1R and IGFBP-3 Between Tumoral and Non-Tumoral Areas in Non-Melanoma Skin Cancers

Gunduz, Ozge; GÖKÖZ, ÖZAY; ERKİN ÖZAYGEN, GÜL; Akan, Tulin

doi:10.5146/tjpath.2013.01185

Comparison of Growth Hormone Receptor, IGF-1R and IGFBP-3 Between Tumoral and Non-Tumoral Areas in Non-Melanoma Skin Cancers

Gunduz O., GÖKÖZ Ö., ERKİN ÖZAYGEN G., Akan T.

TURKISH JOURNAL OF PATHOLOGY, cilt.29, sa.3, ss.185-192, 2013 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.5146/tjpath.2013.01185
Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.185-192
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: A relationship between the pathogenesis of some cancers and growth hormone, insulin-like growth factor-1 and insulin-like growth factors binding protein-3 has been shown. Our aim was to evaluate the expression of growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 in actinic keratosis, basal cell carcinoma and squamous cell carcinoma, and to compare the expression patterns of tumoral areas with normal epidermis and skin appendages.