Evaluation of the neurotoxicity of DMSO infused into the carotid artery of rat

BAKAR, BÜLENT; Kose, SEVDA; Sonal, Sevilay; ALHAN, ASLIHAN; Kilinc, Kamer; Keskil, Ismail

doi:10.1016/j.injury.2011.08.021

Evaluation of the neurotoxicity of DMSO infused into the carotid artery of rat

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BAKAR B., Kose E. A., Sonal S., ALHAN A., Kilinc K., Keskil I. S.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.43, no.3, pp.315-322, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 43 Issue: 3
Publication Date: 2012
Doi Number: 10.1016/j.injury.2011.08.021
Journal Name: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.315-322
Hacettepe University Affiliated: Yes

Abstract

Introduction: Despite the explanations put forth in many studies regarding histopathological evidence of the inflammatory stage related with the infusion of dimethyl sulfoxide (DMSO) in the vessel wall and its lumen, there has been no research to evaluate its neural toxicity when it is infused via the intracarotid route. This study was designed to evaluate the possible neurotoxic effects of DMSO on the closer and distant brain tissue and carotid artery when it was slowly infused into the internal carotid arteries of the rats.