Evaluation of the neurotoxicity of DMSO infused into the carotid artery of rat


BAKAR B., Kose E. A. , Sonal S., ALHAN A., Kilinc K., Keskil I. S.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, cilt.43, ss.315-322, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 43 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.injury.2011.08.021
  • Dergi Adı: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Sayfa Sayıları: ss.315-322

Özet

Introduction: Despite the explanations put forth in many studies regarding histopathological evidence of the inflammatory stage related with the infusion of dimethyl sulfoxide (DMSO) in the vessel wall and its lumen, there has been no research to evaluate its neural toxicity when it is infused via the intracarotid route. This study was designed to evaluate the possible neurotoxic effects of DMSO on the closer and distant brain tissue and carotid artery when it was slowly infused into the internal carotid arteries of the rats.