Pharmacoresistant seizures in neurofibromatosis type 1 related to hippocampal sclerosis: Three case presentation and review

Algin D. I., Tezer F. İ., Oguz K. K., BİLGİNER B., Soylemezoglu F., SAYGI S.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.64, pp.14-17, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 64
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jocn.2019.03.055
  • Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.14-17
  • Keywords: Neurofibromatosis, Hippocampal sclerosis, Intractable seizures epilepsy surgery, UNIDENTIFIED BRIGHT OBJECTS, EPILEPSY, FEATURES, MRI
  • Hacettepe University Affiliated: Yes

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited disorder, with an estimated prevalence of 1 in 3000-4000 people. Seizures occur 4-7% of individuals with NF1, mostly due to associated brain tumors or cortical malformations. Hippocampal sclerosis (HS) in the patients with NF1 has been reported very rarely and only 15 patients were found in review of English literature. We presented here 3 additional patients with NF1 and intractable seizures due to hippocampal sclerosis; in whom one of them underwent epilepsy surgery and he is seizure free for 5 years after right temporal lobectomy. (C) 2019 Elsevier Ltd. All rights reserved.