Hypophosphatemia Due to Adefovir Treatment

Demir, Nazlim; Kolgelier, Servet; Ozcimen, Serap; Aksoz, Selcuk; Inkaya, AHMET

Hypophosphatemia Due to Adefovir Treatment

Demir N. A., Kolgelier S., Ozcimen S., Aksoz S., Inkaya A. C.

MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, cilt.1, 2012 (ESCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 1
Basım Tarihi: 2012
Dergi Adı: MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
Hacettepe Üniversitesi Adresli: Evet

Özet

Adefovir dipivoxil is an orally effective prodrug excreted unchanged in urine by glomerular filtration and tubular secretion. While it effectively suppresses hepatitis B virus replication, it may cause nephrotoxicity characterized by severe hypophosphatemia. In this report, we present a case of isolated hypophosphatemia due to long-term use of adefovir dipivoxil (10 mg/day). Due to the risk of hypophosphatemia with extended use, calcium and serum levels and symptoms suggesting nephrotoxicity should be followed in patients using adefovir dipivoxil for an extended period.