Relationship between hemorheology and endothelial dysfunction in renal transplant patients receiving calcineurin inhibitors

Akoglu H., SERINGEC N., YILDIRIM T., YILMAZ R., Okutucu S., Turkmen E., ...More

JOURNAL OF NEPHROLOGY, vol.26, no.5, pp.931-940, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.5301/jn.5000237
  • Journal Name: JOURNAL OF NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.931-940
  • Hacettepe University Affiliated: Yes

Abstract

Background: Calcineurin inhibitors, mainly cyclosporin A (CsA), are associated with endothelial dysfunction in renal transplant recipients (RTRs). Hemorheological disturbances including decreased erythrocyte deformability (ED), increased plasma viscosity and erythrocyte aggregation (EA) have also been reported in CsA-treated RTRs. The aim of this study was to investigate the relationship between hemorheological factors and endothelial dysfunction in CsA- and tacrolimus (Tc) treated RTRs.