Relationship between hemorheology and endothelial dysfunction in renal transplant patients receiving calcineurin inhibitors

Akoglu, HADİM; SERINGEC, Nurten; YILDIRIM, TOLGA; YILMAZ, Rahmi; Okutucu, SERCAN; Turkmen, ERCAN; EVRANOS, BANU; KAYA, ERGÜN; DIKMENOGLU, NESLİHAN; ARICI, MUSTAFA; Erdem, YUNUS; TURGAN, Cetin

doi:10.5301/jn.5000237

Relationship between hemorheology and endothelial dysfunction in renal transplant patients receiving calcineurin inhibitors

Akoglu H., SERINGEC N., YILDIRIM T., YILMAZ R., Okutucu S., Turkmen E., ...More

JOURNAL OF NEPHROLOGY, vol.26, no.5, pp.931-940, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 26 Issue: 5
Publication Date: 2013
Doi Number: 10.5301/jn.5000237
Journal Name: JOURNAL OF NEPHROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.931-940
Hacettepe University Affiliated: Yes

Abstract

Background: Calcineurin inhibitors, mainly cyclosporin A (CsA), are associated with endothelial dysfunction in renal transplant recipients (RTRs). Hemorheological disturbances including decreased erythrocyte deformability (ED), increased plasma viscosity and erythrocyte aggregation (EA) have also been reported in CsA-treated RTRs. The aim of this study was to investigate the relationship between hemorheological factors and endothelial dysfunction in CsA- and tacrolimus (Tc) treated RTRs.