Oxidant and antioxidant balance in patients with COVID-19.

Aykac K., Ozsurekci Y., Yayla B. C. C., Gurlevik S. L., Oygar P. D., Bolu N. B., ...Daha Fazla

Pediatric pulmonology, cilt.56, sa.9, ss.2803-2810, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/ppul.25549
  • Dergi Adı: Pediatric pulmonology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2803-2810
  • Anahtar Kelimeler: COVID-19, oxidative stress, pediatrics, severity, thiols, OXIDATIVE STRESS, THIOL/DISULFIDE REDOX, ISCHEMIA, THIOLS, MARKER, HOMEOSTASIS, DISULFIRAM, PNEUMONIA, ASSAY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background A crucial balance exists between oxidant and antioxidant mechanisms in the functional immune system. We aimed to evaluate the contributions of balance between these systems to coronavirus disease 2019 (COVID-19), a devastating pandemic caused by viral infection. Method We analyzed serum oxidant and antioxidant stress parameters according to the clinical and demographic characteristics of children and adults with COVID-19 and compared them against the values of healthy controls. Serum native thiol (NT), total thiol (TT), disulfide, total antioxidant status, total oxidant status, and ischemia-modified albumin levels were evaluated and compared between groups. Results A total of 79 children and 74 adults were evaluated in the present study, including 46 children and 40 adults with COVID-19, 33 healthy children, and 34 healthy adults. TT, NT, and disulfide levels were significantly lower in the adult COVID-19 group than in all other groups (p = .001, p = .001, and p = .005, respectively). Additionally, TT and NT levels were significantly lower in both pediatric and adult COVID-19 cases with severe disease course than mild/moderate course. TT and NT levels were identified as predictors for the diagnosis of the adult COVID-19 cases and as independent predictors for disease severity in both children and adults with COVID-19. Conclusion Parameters that reveal the oxidant and antioxidant capacity, including TT and NT, appear to be good candidates for the accurate prediction of the clinical course among patients with COVID-19.