Novel Technologies and Nanotoxicology of Medical Implants

AKÇAN R., AYDOGAN H. C., Yildirim M. S., Tastekin B., SAĞLAM N.

CURRENT ANALYTICAL CHEMISTRY, no.8, pp.1133-1140, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Publication Date: 2021
  • Doi Number: 10.2174/1573411016999200507104128
  • Journal Name: CURRENT ANALYTICAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core
  • Page Numbers: pp.1133-1140
  • Keywords: Biomaterials, medical implants, nanomaterials, nanotechnology, nanotoxicology, therapeutic implementations, FIELD-EFFECT TRANSISTOR, MESENCHYMAL STEM-CELLS, LABEL-FREE DETECTION, IN-VITRO, CARBON NANOTUBES, GOLD NANOPARTICLES, DENTAL IMPLANTS, NANOMATERIALS, BONE, CYTOTOXICITY
  • Hacettepe University Affiliated: Yes

Abstract

Background/Aim: Use of nanomaterials in healthcare applications increases in parallel to technological developments. It is frequently utilized in diagnostic procedures, medications and thera-peutic implementations. Nanomaterials take place among key components of medical implants, which might be responsible for certain toxic effects on human health at nano-level. In this review, nanotoxicological effects, toxicity determination of nanobiomaterials used in human body and their effects on human health are discussed. Materials and Methods: A detailed review of related literature was performed and evaluated as per nanomaterials and medical implants. Results and Conclusion: The nanotoxic effects of the materials applied to human body and the de-termination of its toxicity are important. Determination of toxicity for each nanomaterial requires a detailed and multifactorial assessment considering the properties of these materials. There are limited studies in the literature regarding the toxic effects of nanomaterials used in medical implants. Although these implants are potentially biocompatible and biodegradable, it is highly im-portant to discuss nanotoxicological characteristics of medical implants.