Hypomania in a Schizophrenic Patient Treated with Modafinil for Clozapine-Induced Sedation


ÖZER S. , DEMİR B.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.47, ss.171-173, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 47 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.4274/npa.5474
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Sayfa Sayıları: ss.171-173

Özet

Modafinil is used in the treatment of excessive daytime sleepiness associated with several conditions. Modafinil has also been suggested to improve antipsychotic-associated sedation in patients with schizophrenia. Although a small risk of psychosis exacerbation has been reported due to modafinil adjunct treatment, modafinil-induced mania or hypomania has not been described in schizophrenia up to now. Herein, we present a 31-year-old patient diagnosed as having schizophrenia according to DSM-IV-TR, who developed a hypomanic episode with irritability, motor activation and uninterruptible speech soon after adding modafinil to clozapine. In this context, the risks and benefits of adjunct therapy with modafinil in treatment-resistant schizophrenic patients who have been prescribed clozapine will be discussed. (Archives of Neuropsychiatry 2010; 47: 171-3)