Hypomania in a Schizophrenic Patient Treated with Modafinil for Clozapine-Induced Sedation

ÖZER S., DEMİR B.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.47, no.2, pp.171-173, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.4274/npa.5474
  • Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.171-173
  • Hacettepe University Affiliated: Yes

Abstract

Modafinil is used in the treatment of excessive daytime sleepiness associated with several conditions. Modafinil has also been suggested to improve antipsychotic-associated sedation in patients with schizophrenia. Although a small risk of psychosis exacerbation has been reported due to modafinil adjunct treatment, modafinil-induced mania or hypomania has not been described in schizophrenia up to now. Herein, we present a 31-year-old patient diagnosed as having schizophrenia according to DSM-IV-TR, who developed a hypomanic episode with irritability, motor activation and uninterruptible speech soon after adding modafinil to clozapine. In this context, the risks and benefits of adjunct therapy with modafinil in treatment-resistant schizophrenic patients who have been prescribed clozapine will be discussed. (Archives of Neuropsychiatry 2010; 47: 171-3)