Effects of endothelin receptor blockade and COX inhibition on intestinal I/R injury in a rat model: Experimental research


Ucar B. I. , Erikci A., Kosemehmetoglu K., Ozkul C. , Iskit A. B. , Ucar G. , ...Daha Fazla

INTERNATIONAL JOURNAL OF SURGERY, cilt.83, ss.89-97, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 83
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ijsu.2020.08.061
  • Dergi Adı: INTERNATIONAL JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.89-97

Özet

Background: Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. The present study aimed to investigate the effects of cyclooxygenase (COX) inhibition synchronized with nitric oxide (NO) release and endothelin (ET) receptor blockade on oxidative stress, inflammation, vasoconstriction, and bacterial translocation which occur during ischemia-reperfusion (I/R) injury in in-vivo rat intestinal I/R model.