Effects of endothelin receptor blockade and COX inhibition on intestinal I/R injury in a rat model: Experimental research


Ucar B. I. , Erikci A., Kosemehmetoglu K., Ozkul C., Iskit A. B. , Ucar G., ...More

INTERNATIONAL JOURNAL OF SURGERY, vol.83, pp.89-97, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ijsu.2020.08.061
  • Journal Name: INTERNATIONAL JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.89-97
  • Keywords: Intestinal ischemia reperfusion injury, Rat, Cyclooxygenase inhibition, Endothelia receptor blockers, Nitric oxide

Abstract

Background: Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. The present study aimed to investigate the effects of cyclooxygenase (COX) inhibition synchronized with nitric oxide (NO) release and endothelin (ET) receptor blockade on oxidative stress, inflammation, vasoconstriction, and bacterial translocation which occur during ischemia-reperfusion (I/R) injury in in-vivo rat intestinal I/R model.