Effects of Three Actinic Keratosis Mutations on Apoptosis
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.33, sa.4, ss.197-201, 2008 (SCI-Expanded, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 4
- Basım Tarihi: 2008
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.197-201
- Hacettepe Üniversitesi Adresli: Evet
Özet
Introduction: Ultraviolet radiation contributes to the etiology of skin cancers by generating mutations in the p53 tumor suppressor gene. The incidence of skin cancer is doubling each decade; 95% of these are the non-melanoma skin cancers. Actinic keratosis is a precancerous lesion characterized by aberrant proliferation and cell differentiation that progresses to squamous cell carcinoma at a rate of similar to 0.1% per year. Our aim was to determine whether mutant p53 alleles found in Actinic Keratosis have different phenotypic effects on UVB-induced apoptosis that might explain why only some progress to squamous cell carcinoma.