Effects of Three Actinic Keratosis Mutations on Apoptosis

ERCAN A., OGUS I. H.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.33, no.4, pp.197-201, 2008 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2008
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.197-201
  • Hacettepe University Affiliated: Yes

Abstract

Introduction: Ultraviolet radiation contributes to the etiology of skin cancers by generating mutations in the p53 tumor suppressor gene. The incidence of skin cancer is doubling each decade; 95% of these are the non-melanoma skin cancers. Actinic keratosis is a precancerous lesion characterized by aberrant proliferation and cell differentiation that progresses to squamous cell carcinoma at a rate of similar to 0.1% per year. Our aim was to determine whether mutant p53 alleles found in Actinic Keratosis have different phenotypic effects on UVB-induced apoptosis that might explain why only some progress to squamous cell carcinoma.