Effects of Three Actinic Keratosis Mutations on Apoptosis

ERCAN A., OGUS I. H.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.33, sa.4, ss.197-201, 2008 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.197-201
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Introduction: Ultraviolet radiation contributes to the etiology of skin cancers by generating mutations in the p53 tumor suppressor gene. The incidence of skin cancer is doubling each decade; 95% of these are the non-melanoma skin cancers. Actinic keratosis is a precancerous lesion characterized by aberrant proliferation and cell differentiation that progresses to squamous cell carcinoma at a rate of similar to 0.1% per year. Our aim was to determine whether mutant p53 alleles found in Actinic Keratosis have different phenotypic effects on UVB-induced apoptosis that might explain why only some progress to squamous cell carcinoma.