1

Faculty of Medicine, Pediatric Allergy and Immunology, Marmara University, Istanbul, Turkey

2

The Isil Berat Barlan Center for Translational Medicine, Istanbul Jeffrey Modell Foundation Diagnostic Center for Primary Immune Deficiencies, Istanbul, Turkey

3

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

4

Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden

5

Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

6

Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon

7

Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon

8

Allergy and Immunology Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar

9

Allergy and Clinical Immunology Department, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

10

Necmettin Erbakan University, Faculty of Medicine, Pediatric Allergy and Immunology, Konya, Turkey

11

Laboratory of Immunology, Department of Medical Biology, University of Algiers, Rouiba Hospital, Algiers, Algeria

12

Division of Pediatric Allergy and Immunology, Tawam Hosptial, Abu Dhabi, United Arab Emirates

13

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt

14

Department of Medical Immunology, Beni Messous University Hospital Center, Faculty of Pharmacy, University of Algiers, Algiers, Algeria

15

United Arab Emirates University, College of Medicine and Health Sciences, Department of Pediatrics, Pediatric Infectious Diseases, Al Ain, United Arab Emirates

16

Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey

17

Institut Pasteur de Tunis and University Tunis El Manar, Tunis, Tunisia

18

Department of Pediatrics, Mansoura University Children’s Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt

19

Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

20

King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

21

Department of Pediatrics, Division of Allergy and Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

22

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia

23

Microbiology Department, College of Medicine, Kuwait University, Kuwait, Al-Rashed Allergy Center, Ministry of Health, Kuwait

24

Department of Pediatric Allergy and Clinical Immunology, The Royal Hospital, Muscat, Oman

25

Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman

26

Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon

27

Sheikh Khalifa Medical City-Union 71-Purehealth, Abu Dhabi, United Arab Emirates

28

Bursa Uludag University, Faculty of Medicine, Department of Pediatric Immunology and Rheumatology, Bursa, Turkey

29

Department of Pediatric Immunology and Allergy, University of Health Sciences Dr. Behcet Uz Children’s Hospital, İzmir, Turkey

30

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Pediatric Allergy and Immunology, Istanbul, Turkey

31

Department of Internal Medicine, Division of Immunology and Allergy, Faculty of Medicine, Baskent University, Ankara, Turkey

32

Division of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey

33

Department of Pediatrics, Mustapha Pacha University Hospital, Algiers, Algeria

34

Department of Immunology, Pasteur Institute of Algeria, Faculty of Medicine, Algiers, Algeria

35

Department of Pediatric Immunology, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey

36

Pediatric Allergy, Immunology and Rheumatology Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

37

Queen Rania Children Hospital, Amman, Jordan

38

Department of Immunology, Sidra Medicine, Ar-Rayyan, Qatar

39

Laboratory of Clinical Immunology, Inflammation and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, Department of pediatric infectious and immunological diseases, Ibn Rushd Children Hospital, Casablanca, Morocco

40

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

41

Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait City, Kuwait

42

Allergy and Clinical Immunology Unit, Pediatric Department, Al-Sabah Hospital, Kuwait City, Kuwait

43

Division of Immunology, Boston Children’s Hospital and Harvard Medical School, 1 Blackfan Circle, Karp, Building, Boston, Massachusetts, United State of America

Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared to other regions, probably due to the delay in diagnosis. The MENA-IEI registry network (MIRN) has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations.