Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitis

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Vardar Acar N., Cavkaytar Ö., Arik Yilmaz E., Büyüktiryaki A. B., Uysal Soyer Ö., Şahiner Ü. M., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.50, sa.8, ss.1865-1871, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-1910-162
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1865-1871
  • Anahtar Kelimeler: Atopic dermatitis, filaggrin, food allergy, R501X, 2282del4, R2447X, S3247X, OF-FUNCTION MUTATIONS, NULL MUTATIONS, ICHTHYOSIS VULGARIS, FUNCTION VARIANTS, RISK-FACTORS, FLG GENE, ASTHMA, ECZEMA, DIAGNOSIS, SENSITIZATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background/aim: Filaggrin is a protein complex involved in epidermal differentiation and skin barrier formation. Mutations of the filaggrin gene (FLG) arc associated with allergen sensitization and allergic diseases like atopic dermatitis (AD), allergic rhinitis, food allergy (FA), and asthma. The aim of the study is to reveal the frequency of change in the FIG gene and determine the association between FIG loss-of-function (LOF) mutations and FA and/or AD in Turkish children.