In this study, the effects of washing and drying procedures on deoxynivalenol (DON) and zearalenone (ZEA) levels of a naturally contaminated wheat sample were investigated. Wheat grain was washed with water, chlorinated water, and sodium carbonate and sodium hydroxide solutions for 1 and 2 min with a pressurised washing system. Washed wheat samples were dried by using three different procedures, i.e. oven drying at low temperatures, and microwave and infrared drying. Pressure washing of wheat grains with water followed by oven drying reduced mycotoxin levels with a minimum of 30.3% for DON and 21.1% for ZEA. Infrared and microwave drying of pressure washed grains caused further reductions in DON and ZEA concentrations up to 89.0%. Using chlorinated water, sodium carbonate and sodium hydroxide solutions for 1 min reduced DON levels in the range of 37.3-91.2% and ZEA levels in the range of 31.6-83.6%. The results of this study indicated that pressure washing and microwave and infrared drying are promising methods for decontamination of wheat grains, even at high mycotoxin concentrations.