TETRAHEDRON, vol.63, no.25, pp.5608-5613, 2007 (SCI-Expanded)
Novel 2-alkylated pyrrole derivatives were synthesized regioselectively by Gd(OTf)(3) catalyzed addition reactions of pyrrole to substituted dimethyl 2-benzylidenemalonate derivatives under mild reaction conditions. 2-Alkylated pyrrole derivatives are used for the construction of the 3-oxo pyrrolizine skeleton. Intramolecular cyclization of alkylated pyrrole derivatives afforded new diastereoselective 3-oxo-2,3-dihydro-1H-pyrrolizine derivatives with good to high yields. (C) 2007 Elsevier Ltd. All rights reserved.