Chlorinated Iridoid Glucosides from Veronica longifolia and Their Antioxidant Activity

Jensen S. R., Gotfredsen C. H., HARPUT U. S., SARAÇOĞLU İ.

JOURNAL OF NATURAL PRODUCTS, vol.73, no.9, pp.1593-1596, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.1021/np100366k
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1593-1596
  • Hacettepe University Affiliated: Yes


From Veronica longifolia were isolated three chlorinated iridoid glucosides, namely, asystasioside E (6) and its 6-O-esters 6a and 6b, named longifoliosides A and B, respectively. The structures of 6a and 6b were proved by analysis of their spectroscopic data and by conversion to the catalpol ester verproside (5a) or to catalpol (5), respectively. The configuration of the previously known vanilloyl analogue, urphoside B, was shown to be the 6 beta-epimer (6c) of the structure originally reported. Longifoliosides A (6a) and B (6b) were found to exhibit radical-scavenging activity against nitric oxide, superoxide, and 2,2-diphenyl-1-picrylhydrazyl radicals.