The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma.

Sackesen, CANSIN; Karaaslan, İBRAHİM; KESKİN, ÖZLEM; TOKOL, NİHAN; TAHAN, FULYA; Civelek, ERSOY; Soyer, OU; Adalioglu, GÖNÜL; TUNCER, AYFER; Birben, ESRA; ÖNER, CİHAN; KALAYCI, ÖMER

doi:10.1111/j.1398-9995.2005.00874.x

The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma.

Sackesen C., Karaaslan C., KESKİN Ö., TOKOL N., TAHAN F., Civelek E., ...Daha Fazla

Allergy, cilt.60, sa.12, ss.1485-92, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 60 Sayı: 12
Basım Tarihi: 2005
Doi Numarası: 10.1111/j.1398-9995.2005.00874.x
Dergi Adı: Allergy
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1485-92
Anahtar Kelimeler: asthma, CD14, endotoxin, IgE, TLR4, TOLL-LIKE RECEPTOR-4, HOUSE-DUST ENDOTOXIN, SERUM IGE LEVELS, ATOPIC ASTHMA, LIPOPOLYSACCHARIDE, EXPOSURE, ASSOCIATION, HYPORESPONSIVENESS, CHALLENGE, MUTATIONS
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Endotoxin, with its potential to enhance type 1 immunity, is a significant player in the hygiene hypothesis. The combined effects of the genetic variants of various molecules in the endotoxin response pathway on asthma related phenotypes are largely unknown.