The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma.

Sackesen C., Karaaslan C., KESKİN Ö., TOKOL N., TAHAN F., Civelek E., ...More

Allergy, vol.60, no.12, pp.1485-92, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1398-9995.2005.00874.x
  • Journal Name: Allergy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1485-92
  • Keywords: asthma, CD14, endotoxin, IgE, TLR4, TOLL-LIKE RECEPTOR-4, HOUSE-DUST ENDOTOXIN, SERUM IGE LEVELS, ATOPIC ASTHMA, LIPOPOLYSACCHARIDE, EXPOSURE, ASSOCIATION, HYPORESPONSIVENESS, CHALLENGE, MUTATIONS
  • Hacettepe University Affiliated: Yes

Abstract

Background: Endotoxin, with its potential to enhance type 1 immunity, is a significant player in the hygiene hypothesis. The combined effects of the genetic variants of various molecules in the endotoxin response pathway on asthma related phenotypes are largely unknown.