Effects of Probiotic Bacteria on Central Neuronal Activation in Experimental Colitis
TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.33, sa.4, ss.304-311, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.5152/tjg.2022.201175
- Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.304-311
- Anahtar Kelimeler: C-fos, gut-brain axis, inflammatory bowel disease, lactobacillus, probiotic, INFLAMMATORY-BOWEL-DISEASE, GUT-BRAIN AXIS, MICROBIOTA, ANXIETY, STRESS
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Brain-gut axis dysregulation is observed in inflammatory bowel disease. However, the effect of altered gut flora on neuro-immunomodulation and its role in the pathogenesis of inflammatory bowel disease are unknown. The aims of this study are to determine (i) whether colitis modifies the expression of c-fos, a marker of general neuronal activation in the brain and (ii) whether this activation could be modulated by probiotic bacteria.