Effects of Probiotic Bacteria on Central Neuronal Activation in Experimental Colitis

Sengul N., Tore F., Isik S., ASLIM B., UÇAR G., FIRAT T., ...More

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.33, no.4, pp.304-311, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.5152/tjg.2022.201175
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.304-311
  • Keywords: C-fos, gut-brain axis, inflammatory bowel disease, lactobacillus, probiotic, INFLAMMATORY-BOWEL-DISEASE, GUT-BRAIN AXIS, MICROBIOTA, ANXIETY, STRESS
  • Hacettepe University Affiliated: Yes


Background: Brain-gut axis dysregulation is observed in inflammatory bowel disease. However, the effect of altered gut flora on neuro-immunomodulation and its role in the pathogenesis of inflammatory bowel disease are unknown. The aims of this study are to determine (i) whether colitis modifies the expression of c-fos, a marker of general neuronal activation in the brain and (ii) whether this activation could be modulated by probiotic bacteria.