Effects of Probiotic Bacteria on Central Neuronal Activation in Experimental Colitis

Sengul N., Tore F., Isik S., ASLIM B., UÇAR G., FIRAT T., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.33, sa.4, ss.304-311, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5152/tjg.2022.201175
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.304-311
  • Anahtar Kelimeler: C-fos, gut-brain axis, inflammatory bowel disease, lactobacillus, probiotic, INFLAMMATORY-BOWEL-DISEASE, GUT-BRAIN AXIS, MICROBIOTA, ANXIETY, STRESS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Brain-gut axis dysregulation is observed in inflammatory bowel disease. However, the effect of altered gut flora on neuro-immunomodulation and its role in the pathogenesis of inflammatory bowel disease are unknown. The aims of this study are to determine (i) whether colitis modifies the expression of c-fos, a marker of general neuronal activation in the brain and (ii) whether this activation could be modulated by probiotic bacteria.