Autistic children have problems in cognitive and motor skills areas. This study investigated the effects of motor and cognitive problems on daily living activities and quality of life in autistic children. Thirty-two autistic children were included in the study. Thirty typically developing children were selected as the control group. The Bruininks Oseretsky Test of Motor Proficiency, Lowenstein Occupational Therapy Cognitive Assessment, Pediatric Evaluation Disability Inventory, Child Health Questionnaire were used to assess motor proficiency, cognitive abilities, daily living activities and quality of life, respectively. This study shows cognitive and motor impairment negatively affects daily living activities in children with autism.