Simulating the propagation of spreading cortical depression (SCD) wavefront on human brain surface


Baysal U., HAUEISEN J., DURGUT K., DEMIRCI M.

COMPUTERS IN BIOLOGY AND MEDICINE, vol.37, no.10, pp.1446-1454, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1016/j.compbiomed.2007.01.004
  • Journal Name: COMPUTERS IN BIOLOGY AND MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1446-1454

Abstract

Spreading cortical depression (SCD) is a slowly spreading supression of electroencephalogram (EEG) activity that was first observed in anaesthetized rabbits in 1944. Since then, the spatial properties of propagation have been investigated on numerous animal experiments. In the folded and complex human cortex, both the occurrence of SCD and the relationship between SCD and migraine have been discussed controversially. This study proposes a software tool to simulate the possible wavefront motion on the surface of human brain. The SCD wavefront motion has been simulated up to an affected surface region of roughly 150 cm(2) and validated by clinical experts. (c) 2006 Elsevier Ltd. All rights reserved.