A general overview on endocrine disrupting chemicals and their mechanism of action Endokrin bozucu kimyasal maddelere ve etki mekanizmalarına genel bir bakış


Yildiz Fendoğlu B., Koçer-Gümüşel B., Erkekoğlu P.

Hacettepe University Journal of the Faculty of Pharmacy, vol.39, no.1, pp.30-43, 2019 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Review
  • Volume: 39 Issue: 1
  • Publication Date: 2019
  • Journal Name: Hacettepe University Journal of the Faculty of Pharmacy
  • Journal Indexes: Scopus
  • Page Numbers: pp.30-43

Abstract

© 2019, Hacettepe University, Faculty of Pharmacy. All rights reserved.Nowadays, the studies for the impact of endocrine disrupting chemicals on the environment and humans are gaining interest. Endocrine disrupting chemicals can cause adverse effects on individuals or future generations by altering the regular functioning of the endocrine system. Humans are exposed to these chemicals from various sources. These sources are mainly foods, packaging materials, cosmetics and medicines. The most important basic critical factor for their toxic effects after exposure to these chemicals is the age of exposure. Prenatal and early postnatal exposures may particularly cause more severe toxic effects. In addition, the structural properties of the endocrine disruptors and exposure their mixtures can affect the extent of the toxicity. Though the toxic mechanisms of action for endocrine disrupting chemicals is not well-known, they are suggested to cause toxicity with one or more toxic effects like oxidative stress, genotoxic and epigenetic effects, interaction with nuclear receptors and increasing sensitivity to endogenous hormones. In this review, we will focus on the uses, classifications, mechanisms of action and toxic effects of endocrine disrupting chemicals on organs/systems.