Upgrading of bio-separation and bioanalysis using synthetic polymers: Molecularly imprinted polymers (MIPs), cryogels, stimuli-responsive polymers


ASLIYÜCE ÇOBAN S., İDİL N., Mattiasson B.

ENGINEERING IN LIFE SCIENCES, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Publication Date: 2022
  • Doi Number: 10.1002/elsc.202100106
  • Journal Name: ENGINEERING IN LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Compendex, EMBASE, Food Science & Technology Abstracts, Geobase, Veterinary Science Database
  • Keywords: cryogels, molecular imprinting, separation, smart polymers, synthetic polymers, two-phase systems, COMPOSITE CRYOGEL, FERMENTATION BROTH, ALBUMIN DEPLETION, 2-PHASE SYSTEMS, PURIFICATION, REMOVAL, ACID, IMMUNOGLOBULIN, CHROMATOGRAPHY, CELLULOSE

Abstract

Bio-separation plays a crucial role in many areas. Different polymers are suitable for bio-separation and are useful for applications in applications in both science and technology. Besides biopolymers, there are a broad spectrum of synthetic polymers with tailor-made properties. The synthetic polymers are characterized by their charges, solubility, hydrophilicity/hydrophobicity, sensitivity to environmental conditions and stability. Furthermore, ongoing developments are of great interest on biodegradable polymers for the treatment of diseases. Smart polymers have gained great attention due to their unique characteristics especially emphasizing simultaneously changing their chemical and physical property upon exposure to changes in environmental conditions. In this review, methodologies applied in bio-separation using synthetic polymers are discussed and efficient candidates are focused for the construction of synthetic polymers.