Role of natural killer cells in lung cancer


Aktas O. N. , Ozturk A. B. , Erman B. , Erus S., Tanju S., Dilege S.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.144, no.6, pp.997-1003, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 144 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1007/s00432-018-2635-3
  • Title of Journal : JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Page Numbers: pp.997-1003
  • Keywords: Immunotherapy, Lung cancer, Natural killer cells, Non-small cell lung cancer, Small cell lung cancer, NK CELLS, CIGARETTE-SMOKE, T-CELLS, ADOPTIVE IMMUNOTHERAPY, MEDIATED CYTOTOXICITY, IMMUNE RESPONSIVENESS, PERIPHERAL-BLOOD, DENDRITIC CELLS, MOUSE MODEL, EXPRESSION

Abstract

Purpose One of the key immune cells involved in the pathogenesis of lung cancer is natural killer (NK) cells and these cells are novel targets for therapeutic applications in lung cancer. The purpose of this review is to summarize the current literature on lung cancer pathogenesis with a focus on the interaction between NK cells and smoking, how these factors are related to the pathogenesis of lung cancer and how NK cell-based immunotherapy effect lung cancer survival.