Role of natural killer cells in lung cancer

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Aktas O. N., Ozturk A. B., Erman B., Erus S., Tanju S., Dilege S.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.144, sa.6, ss.997-1003, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 144 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00432-018-2635-3
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.997-1003
  • Anahtar Kelimeler: Immunotherapy, Lung cancer, Natural killer cells, Non-small cell lung cancer, Small cell lung cancer, NK CELLS, CIGARETTE-SMOKE, T-CELLS, ADOPTIVE IMMUNOTHERAPY, MEDIATED CYTOTOXICITY, IMMUNE RESPONSIVENESS, PERIPHERAL-BLOOD, DENDRITIC CELLS, MOUSE MODEL, EXPRESSION
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Purpose One of the key immune cells involved in the pathogenesis of lung cancer is natural killer (NK) cells and these cells are novel targets for therapeutic applications in lung cancer. The purpose of this review is to summarize the current literature on lung cancer pathogenesis with a focus on the interaction between NK cells and smoking, how these factors are related to the pathogenesis of lung cancer and how NK cell-based immunotherapy effect lung cancer survival.