The Clinical Significance of Serum Apoptotic Cytokeratin 18 Neoepitope M30 (CK-18 M30) and Matrix Metalloproteinase 2 (MMP-2) Levels in Chronic Hepatitis B Patients with Cirrhosis

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Sumer S., DEMIR N. A., Kolgelier S., İNKAYA A. Ç., Arpaci A., DEMIR L. S., ...More

HEPATITIS MONTHLY, vol.13, no.6, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.5812/hepatmon.10106
  • Journal Name: HEPATITIS MONTHLY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Hepatitis B, Chronic, Cirrhosis, Liver Cirrhosis, Matrix Metalloproteinase 2, CHRONIC VIRAL-HEPATITIS, LIVER FIBROSIS, NATURAL-HISTORY, MARKERS, EXPRESSION, SEVERITY, HCV, ACTIVATION, INFECTION
  • Hacettepe University Affiliated: Yes

Abstract

Background: Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. CK-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. MMP-2 plays an important role in tissue remodeling and repairing processes during physiological and pathological states.