The Clinical Significance of Serum Apoptotic Cytokeratin 18 Neoepitope M30 (CK-18 M30) and Matrix Metalloproteinase 2 (MMP-2) Levels in Chronic Hepatitis B Patients with Cirrhosis


Sumer S., DEMIR N. A. , Kolgelier S., İNKAYA A. Ç. , Arpaci A., DEMIR L. S. , ...Daha Fazla

HEPATITIS MONTHLY, cilt.13, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 13 Konu: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5812/hepatmon.10106
  • Dergi Adı: HEPATITIS MONTHLY

Özet

Background: Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. CK-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. MMP-2 plays an important role in tissue remodeling and repairing processes during physiological and pathological states.