We investigated sexual dysfunction and accompanying depression in patients with neurodermatitis and psoriasis. Patients with neurodermatitis (n = 31) and psoriasis (n = 24) were compared to control cases (n = 33) with Beck depression scale (BDS) and Arizona Sexual Experience Scale (ASEX). Beck Depression Scale and ASEX scores varied between three groups. In two group comparisons, the neurodermatitis group had more sexual problems than the psoriasis group and the control group. Patients with neurodermatitis and psoriasis have sexual dysfunction and depression in the course of these chronic diseases and the higher frequency of sexual problems was seen in patients with neurodermatitis.