The Correlation Between Reactive Oxygen Species and Histopathology of the Liver, Gut, and Kidneys in Animals with Elevated Intra-abdominal Pressure


Ozmen M. M. , Zulfikaroglu B., Besler T. H. , Col C., Cinel L., Cinel I.

JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, vol.19, no.3, pp.339-343, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1089/lap.2008.0293
  • Journal Name: JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.339-343

Abstract

Background: Clinical and experimental studies have shown that the laparoscopic procedure provides a typical model of ischemia-reperfusion injury in the organs by oxygen-derived free radicals. A pneumoperitoneum produces ischemia during insufflation and reperfusion during desufflation. The aim of this study was to assess the causative role of free radical-mediated reactions in tissue damage under different intra-abdominal insufflation pressures.