The Correlation Between Reactive Oxygen Species and Histopathology of the Liver, Gut, and Kidneys in Animals with Elevated Intra-abdominal Pressure


Ozmen M. M., Zulfikaroglu B., Besler T. H., Col C., Cinel L., Cinel I.

JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, cilt.19, sa.3, ss.339-343, 2009 (SCI-Expanded) identifier identifier identifier

Özet

Background: Clinical and experimental studies have shown that the laparoscopic procedure provides a typical model of ischemia-reperfusion injury in the organs by oxygen-derived free radicals. A pneumoperitoneum produces ischemia during insufflation and reperfusion during desufflation. The aim of this study was to assess the causative role of free radical-mediated reactions in tissue damage under different intra-abdominal insufflation pressures.