Biological classification of childhood arthritis: roadmap to a molecular nomenclature

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Nigrovic P. A., Colbert R. A., Holers V. M., ÖZEN S., Ruperto N., Thompson S. D., ...Daha Fazla

NATURE REVIEWS RHEUMATOLOGY, cilt.17, sa.5, ss.257-269, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1038/s41584-021-00590-6
  • Dergi Adı: NATURE REVIEWS RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.257-269
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course. Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least one phenotype might be restricted to children. Nevertheless, paediatric and adult rheumatologists have historically addressed disease classification separately, yielding a juvenile idiopathic arthritis (JIA) nomenclature that exhibits no terminological overlap with adult-onset arthritis. Accumulating clinical, genetic and mechanistic data reveal the critical limitations of this strategy, necessitating a new approach to defining biological categories within JIA. In this Review, we provide an overview of the current evidence for biological subgroups of arthritis in children, delineate forms that seem contiguous with adult-onset arthritis, and consider integrative genetic and bioinformatic strategies to identify discrete entities within inflammatory arthritis across all ages.