Are lymphoblastoid cell lines suitable to study increased SMN gene expression by histone deacetylase inhibitors?

DAYANGAÇ ERDEN D., Topaloglu H., YURTER H.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.1, pp.7-12, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2008
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.7-12
  • Hacettepe University Affiliated: Yes

Abstract

Aim: In this preliminary study, we aimed to analyze the effect of sodium butyrate (NB) and phenylbutyrate (PB), belonging to the class of histone deacetylase (HDAC) inhibitors, on lymphoblastoid cell lines established from spinal muscular atrophy (SMA) patients. Materials and