Extent of coronary atherosclerosis and homocysteine affect endothelial markers

Yildirir A., Tokgozoglu S., Haznedaroglu I., Sinici I., Kabakci G., Ovunc K., ...Daha Fazla

ANGIOLOGY, cilt.52, ss.589-596, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 52 Konu: 9
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1177/000331970105200902
  • Dergi Adı: ANGIOLOGY
  • Sayfa Sayıları: ss.589-596


The aim of the study was to evaluate the effects of the presence, extent, and clinical stability of coronary artery disease on endothelial function parameters, C-reactive protein and homocysteine levels. Fifty-eight patients with angiographically documented coronary artery disease and 25 patients with normal coronary arteries were evaluated for risk factors, plasma homocysteine, C-reactive protein, and soluble adhesion molecule levels. Vascular cell adhesion molecule-1 and sE-selectin were significantly higher in the group with coronary artery disease than in healthy subjects (p = 0.005 and p = 0.031, respectively). Patients with unstable angina had significantly higher C-reactive protein (p < 0.001), troponin I (p < 0.01), and leukocyte counts (p < 0.05) than those with stable angina. sE-selectin levels were correlated with the extent of coronary atherosclerosis (r = 0.444, p < 0.05), and plasma homocysteine levels were associated with vascular cell adhesion molecule-1 (r = 0.479, p < 0.05) in unstable cases. These results suggest that vascular cell adhesion molecule-1 and sE-selectin are useful for determining the presence of coronary atherosclerosis, whereas C-reactive protein, troponin I, and leukocyte count are predictors of clinical stability.