Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells


Vural A. C. , Odabas S., KORKUSUZ P. , Saglam A. S. Y. , BİLGİÇ E. , Cavusoglu T., ...Daha Fazla

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.45, ss.544-550, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3109/21691401.2016.1160918
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Sayfa Sayıları: ss.544-550

Özet

Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.