Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells

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Atıf İçin Kopyala

Vural A. C., Odabas S., KORKUSUZ P., Saglam A. S. Y., BİLGİÇ E., Cavusoglu T., ...Daha Fazla

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.45, sa.3, ss.544-550, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 45 Sayı: 3
• Basım Tarihi: 2017
• Doi Numarası: 10.3109/21691401.2016.1160918
• Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.544-550
• Hacettepe Üniversitesi Adresli: Evet

Özet

Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.