Effect of trapidil in ischemia/reperfusion injury of peripheral nerves

Bagdatoglu C., Saray A., Surucu H., Ozturk H., Tamer L.

NEUROSURGERY, cilt.51, sa.1, ss.212-219, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Konu: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1097/00006123-200207000-00031
  • Sayfa Sayıları: ss.212-219


OBJECTIVE: Ischemia plays an important role in the development of pathological changes in nerve tissue, and restoration of blood flow results in injury (ischemia/ reperfusion [I/R] injury) mediated by toxic oxygen free radicals. Trapidil is currently used as a coronary artery vasodilating agent and is also used for the prevention of ischemic symptoms of cerebral vasospasm. The purpose of this study was to determine the effects of trapidil on I/R injury and the ischemic tolerance of rat peripheral nerves.