Effect of trapidil in ischemia/reperfusion injury of peripheral nerves

Bagdatoglu C., Saray A., Surucu H., Ozturk H., Tamer L.

NEUROSURGERY, vol.51, no.1, pp.212-219, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1097/00006123-200207000-00031
  • Journal Name: NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.212-219
  • Hacettepe University Affiliated: No

Abstract

OBJECTIVE: Ischemia plays an important role in the development of pathological changes in nerve tissue, and restoration of blood flow results in injury (ischemia/ reperfusion [I/R] injury) mediated by toxic oxygen free radicals. Trapidil is currently used as a coronary artery vasodilating agent and is also used for the prevention of ischemic symptoms of cerebral vasospasm. The purpose of this study was to determine the effects of trapidil on I/R injury and the ischemic tolerance of rat peripheral nerves.