Role of inflammation in intrahepatic cholestasis of pregnancy


Biberoglu E., Kirbas A., Daglar K., Kara O., KARABULUT E., Yakut H. I. , ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.42, no.3, pp.252-257, 2016 (SCI-Expanded) identifier identifier identifier

Abstract

AimIntrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterized by elevated serum total bile acid and/or transaminase concentration, and pruritus. Interleukin-6 (IL-6) is a key regulator of the immune response, hematopoiesis and inflammation. We examined both IL-6 and the frequently used inflammatory marker high-sensitivity C-reactive protein (hs-CRP) at baseline in the same study population as for the primary endpoint, in order to provide a new perspective on the pathogenesis of ICP.