Role of inflammation in intrahepatic cholestasis of pregnancy

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Biberoglu E., Kirbas A., Daglar K., Kara O., KARABULUT E., Yakut H. I., ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.42, no.3, pp.252-257, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 42 Issue: 3
• Publication Date: 2016
• Doi Number: 10.1111/jog.12902
• Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.252-257
• Hacettepe University Affiliated: Yes

Abstract

AimIntrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterized by elevated serum total bile acid and/or transaminase concentration, and pruritus. Interleukin-6 (IL-6) is a key regulator of the immune response, hematopoiesis and inflammation. We examined both IL-6 and the frequently used inflammatory marker high-sensitivity C-reactive protein (hs-CRP) at baseline in the same study population as for the primary endpoint, in order to provide a new perspective on the pathogenesis of ICP.