Role of inflammation in intrahepatic cholestasis of pregnancy

Biberoglu E., Kirbas A., Daglar K., Kara O., KARABULUT E., Yakut H. I., ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.42, no.3, pp.252-257, 2016 (SCI-Expanded) identifier identifier identifier


AimIntrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterized by elevated serum total bile acid and/or transaminase concentration, and pruritus. Interleukin-6 (IL-6) is a key regulator of the immune response, hematopoiesis and inflammation. We examined both IL-6 and the frequently used inflammatory marker high-sensitivity C-reactive protein (hs-CRP) at baseline in the same study population as for the primary endpoint, in order to provide a new perspective on the pathogenesis of ICP.