Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Sahin Z., Bicakcigil M., AKSU K., Kamali S., Akar S., ÖNEN F., ...More

ARTHRITIS RESEARCH & THERAPY, vol.14, no.1, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1186/ar3730
  • Journal Name: ARTHRITIS RESEARCH & THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Hacettepe University Affiliated: Yes

Abstract

Introduction: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Beh et's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B* 52 as susceptibility and severity factors.