Familial Mediterranean fever: current perspectives

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Sonmez H. E., Batu E. D., ÖZEN S.

JOURNAL OF INFLAMMATION RESEARCH, cilt.9, ss.13-20, 2016 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2147/jir.s91352
  • Dergi Adı: JOURNAL OF INFLAMMATION RESEARCH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.13-20
  • Anahtar Kelimeler: familial Meditarranean fever, recommendation, child, PHENOTYPE-GENOTYPE CORRELATION, MEFV MUTATIONS, AUTOINFLAMMATORY DISEASES, COLCHICINE-RESISTANT, EXPRESSION PATTERNS, ETHNIC-GROUPS, RISK-FACTORS, CHILDREN, PYRIN, AMYLOIDOSIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Familial Mediterranean fever (FMF) is the most frequent monogenic autoinflammatory disease, and it is characterized by recurrent attacks of fever and polyserositis. The disease is associated with mutations in the MEFV gene encoding pyrin, which causes exaggerated inflammatory response through uncontrolled production of interleukin 1. The major long-term complication of FMF is amyloidosis. Colchicine remains the principle therapy, and the aim of treatment is to prevent acute attacks and the consequences of chronic inflammation. With the evolution in the concepts about the etiopathogenesis and genetics of the disease, we have understood that FMF is more complicated than an ordinary autosomal recessive monogenic disorder. Recently, recommendation sets have been generated for interpretation of genetic testing and genetic diagnosis of FMF. Here, we have reviewed the current perspectives in FMF in light of recent recommendations.