Searching low-energy conformations of two elastin sequences

Creative Commons License

Arkin H.

EUROPEAN PHYSICAL JOURNAL B, vol.37, no.2, pp.223-228, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1140/epjb/e2004-00050-0
  • Journal Name: EUROPEAN PHYSICAL JOURNAL B
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.223-228
  • Hacettepe University Affiliated: No

Abstract

The three-dimensional structures of two common repeat motifs Val(1)-Pro(2)-Gly(3)-Val(4)-Gly(5) and Val(1)-Gly(2)-Val(3)-Pro(4)-Gly(5)-Val(6)-Gly(7)-Val(8)-Pro(9) of tropoelastin are investigated by using the multicanonical simulation procedure. By minimizing the energy structures along the trajectory the thermodynamically most stable low-energy microstates of the molecule are determined. The structural predictions are in good agreement with X-ray diffraction experiments.