Monocyte/HDL-cholesterol ratio predicts the definite stent thrombosis after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction


Cetin E. H. O. , Cetin M. S. , Canpolat U., Aydin S., Topaloglu S., Aras D., ...More

BIOMARKERS IN MEDICINE, vol.9, no.10, pp.967-977, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.2217/bmm.15.74
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.967-977
  • Keywords: inflammation, monocyte to HDL ratio, PCI, ST elevation myocardial infarction, stent thrombosis, HIGH-DENSITY-LIPOPROTEIN, STABLE ANGINA, BARE-METAL, ATHEROSCLEROSIS, EFFLUX, TRIALS, RISK
  • Hacettepe University Affiliated: No

Abstract

Aim: We investigated the predictive value of monocyte count to HDL ratio (M/H ratio) for stent thrombosis (ST) in ST elevation myocardial infarction (STEMI). Patients & methods: 1170 STEMI patients treated with primary PCI were followed-up for a median of 37.2 months. Results: During follow-up, 112 patients were diagnosed as 'definite' ST. The rate of ST was significantly highest in the third M/H ratio tertile. In Cox regression analysis, adjusted for other factors, having an M/H ratio in third tertile had a 2.2-fold increased risk of ST. Kaplan-Meier analysis revealed the higher occurrence of ST in the third tertile compared with others (p < 0.001). Conclusion: M/H ratio as a novel marker of inflammation seemed to be an independent predictor of ST in STEMI patients.