Introduction: The purpose of this study was to evaluate the effect of low surface tension EDTA solutions on the push-out bond strength of resin-based sealer to young and old root canal dentin. Methods: Root canals from 64 (n = 32 age <30 years old and n = 32 >60 years old) extracted, decoronized, single-rooted human teeth were prepared with ProTaper rotary instruments (Dents ply Maillefer, Ballaigues, Switzerland) up to size F4 using 3 mL 2.5% sodium hypochlorite (NaOCI) between each file. Each group was divided into 4 subgroups as follows: 3 mL EDTA, REDTA (17% EDTA + 0.84 g cetyl-trimethylammonium bromide; Sigma-Aldrich, St Louis, MO), EDTA-T (17% EDTA + 1.25% sodium lauryl ether sulfate, Sigma-Aldrich), and saline as the control (n = 8). The final irrigation was completed with 3 mL saline after 3 mL NaOCI in the experimental groups and 3 mL saline in the control group. After root canal filling with gutta-percha (GP) cones/AH Plus sealer (Dentsply, Petropolis, RJ, Brazil), samples were stored at 37 degrees C and 100% humidity for 2 weeks. One-millimeter-thick horizontal sections from the coronal and midthirds of each root were sliced, and push-out bond strength values were measured using a universal testing machine. Data were analyzed using 2-way analysis of variance followed by the Bonferroni test (P < .05). Results: EDTA-T, REDTA, and EDTA significantly increased the bond strength values of GP/AH Plus to the root canal dentin compared with saline in both young and old groups (P < .05). EDTA-T treatment provided higher bond strength values in young dentin compared with EDTA and EDTA-T treated old dentin (P < .05). Conclusions: The bond strength values of GP/AH Plus could be altered depending on age and the type of EDTA compounds.