Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis

Bayrak, Ahmet; Bayrak, Tulin; TOKGÖZOĞLU, SADBERK; VOLKAN SALANCI, BİLGE; Deniz, Ali; YAVUZ, BÜNYAMİN; ALİKAŞİFOĞLU, MEHMET; Demirpence, Ediz

doi:10.5551/jat.11320

Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis

Bayrak A., Bayrak T., TOKGÖZOĞLU S. L., VOLKAN SALANCI B., Deniz A., YAVUZ B., ...Daha Fazla

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.19, sa.4, ss.376-384, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.5551/jat.11320
Dergi Adı: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.376-384
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Aim: Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis. The aim of this study was to investigate the possible relationship between serum paraoxonase (PONase), homocysteine thiolactonase (HTase) activities and PON1 Q192R polymorphism, and the extent and severity of atherosclerosis.