Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis

Creative Commons License

Bayrak A., Bayrak T., TOKGÖZOĞLU S. L., VOLKAN SALANCI B., Deniz A., YAVUZ B., ...More

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, vol.19, no.4, pp.376-384, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5551/jat.11320
  • Journal Name: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.376-384
  • Hacettepe University Affiliated: Yes

Abstract

Aim: Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis. The aim of this study was to investigate the possible relationship between serum paraoxonase (PONase), homocysteine thiolactonase (HTase) activities and PON1 Q192R polymorphism, and the extent and severity of atherosclerosis.