Polyphenolic compounds from Geranium pratense and their free radical scavenging activities.

Akdemir Z., Tatli İ. İ., Saracoglu I., Ismailoglu U., Sahin-Erdemli I., Calis I.

Phytochemistry, vol.56, no.2, pp.189-93, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2001
  • Doi Number: 10.1016/s0031-9422(00)00367-8
  • Journal Name: Phytochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.189-93
  • Keywords: Geranium pratense subsp finitimum (Woronow) Knuth, Geraniaceae, flavonoid, myricetin 3-O-(2 '-O-galloyl)-beta-D-glucopyranoside, (-)-6-chloroepicatechin, free radical scavenger, ENDOTHELIUM-DEPENDENT RELAXATION, RAT AORTIC RINGS, REPERFUSION INJURY, DYSFUNCTION, GLYCOSIDES, FLAVONOIDS, IMPAIRMENT
  • Hacettepe University Affiliated: Yes


Two new polyphenolic compounds, myricetin 3-O-(2"-O-galloyl)-beta -D-glucopyranoside and (-)-6-chloroepicatechin, were isolated from the aerial parts of Geranium pratense subsp. finitimum (Woronow) Knuth, along with three known polyphenolic compounds [quercetin 3-O-(2"-O-galloyl)-beta -D-glucopyranoside, quercetin 3-O-(2"-O-galloyl)-beta -D-galactopyranoside, methyl gallate] and tryptophan. Quercetin 3-O-beta -D-glucopyranoside, quercetin 3-O-beta -D-galactopyranoside, quercetin 3-O-(2"-O-galloyl)-beta -D-glucopyranoside and quercetin 3-O-(2"-O-galloyl)-beta -D-galactopyranoside were found to be effective against free radical induced impairment of endothelium-dependent relaxation in isolated rat aorta. (C) 2001 Elsevier Science Ltd. All rights reserved.